Risk of ischemic heart disease (IHS) based on depression scores at study entry in twins from the study of middle-aged Danish twins (MADTs) and the longitudinal study on aging Danish twins (LSADT). Multifactorial adjusted is for age (as the underlying time scale), gender, cohort, calender year, smoke status, alcohol consumption, body mass index, self-reported diabetes, and self-reported hypertension. HR, hazard ratio; CI, confidence interval.