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. Author manuscript; available in PMC: 2021 Oct 13.
Published in final edited form as: Mol Psychiatry. 2020 Oct 12;26(7):3134–3151. doi: 10.1038/s41380-020-00909-x

Figure 5. A model for cocaine-sensitivity of 3D chromatin organization at the IRXA gene cluster.

Figure 5.

Cocaine dependence is associated with decreased intragenic methylation of IRX2, which may increase IRXA gene expression through CTCF-mediated chromatin architecture.