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. 2021 Apr 9;41(4):BSR20204293. doi: 10.1042/BSR20204293

Figure 4. silenced COL5A2 decreased the migration of GC cells in vitro and in vivo.

Figure 4

(A) Comparison of COL5A2 expression in normal gastric epithelial cells (GES-1) and various gastric cancer cell lines (SGC-7901, MGC-803, HGC-27, AGS, and MKN-45). (B) COL5A2 expression in SGC-7901 and MGC-803 cells after interference. (C and D) Scratch wound detected the migration ability of gastric cancer cells comparing the control and siCOL5A2 groups. (E) Transwell detected the migration ability of gastric cancer cells comparing the control and siCOL5A2 groups. (F) Gross model of liver metastatic nodules in nude mice. (G) HE staining showed metastatic SGC-7901 cells. (H) Immunohistochemistry showed that COL5A2 in tissue was successfully knocked down in the siCOL5A2 group. (I) Statistical comparison of the number of metastatic nodules in the two groups. **P<0.01; ***P<0.001. P<0.05 represents statistical significance.