Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 29;8:640974. doi: 10.3389/fmed.2021.640974

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Tretter, Wolkenhauer, Meyer-Hermann, Dietrich, Green, Marcum and Weckwerth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The hypothalamus-pituitary-adrenal (HPA) axis is the major stress mediator system on an intermediate time scale. It is stimulated by catecholamines (representing the fast stress system) and inhibited by thyroid hormones (as slow mediators of stress and allostatic load). In addition, it has multiple antagonists inhibiting partial functions at peripheral levels of the processing structure, some of them (marked by *) resulting from ACE2 activation. AT, angiotensin; STH, somatotropic hormone. For more details see text.