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. 2021 Mar 29;12:630380. doi: 10.3389/fimmu.2021.630380

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Copyright © 2021 Lin, Chen, Wei, Lin, Chen, Liu, Hsieh, Huang, Lin, Wang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effect of GSK2837808A on MSU-induced peritonitis. (A) Schematic presentation of MSU-induced peritonitis in mice. (B) Determination by ELISA of IL-1β in the peritonea of mice treated for 4 h with intraperitoneal injection of MSU in the presence or absence of GSK2837808A. (C) Absolute number of CD45⁺/CD11b⁺/Ly6G⁺ neutrophils in the peritonea of mice treated for 4 h with intraperitoneal injection of MSU in the presence or absence of GSK2837808A. Each symbol represents an individual mouse (n = 5 per group); small horizontal lines indicate the mean ± SD of the data from two independent experiments. All results were analyzed with the ANOVA test followed by post hoc test. **P < 0.01.