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. 2021 Apr 7;14:2379–2395. doi: 10.2147/OTT.S297140

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© 2021 Li et al.

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Mechanism of circRNA binding to microRNA. On the left, it shows the regulatory effects of microRNA on tumor glucose metabolism under normal conditions, and the ago-microRNA complexes can bind to transporters, enzymes, transcription factors or genes, signaling pathways and produce regulatory effects. On the right, in tumor cells, abnormal expression of circRNA formed by the head and tail splicing of pre-RNA is observed. The circRNAs bind to the ago-microRNA complexes as molecular sponges, making microRNA unable to bind to transporters, enzymes and kinases, transcription factors, genes and signaling pathways. Thus, the original regulatory effect of microRNA on tumor glucose metabolism is inhibited.