Table 6.

Univariate and multivariate analyses for 12-month progression-free survival

	Univariate		Multivariate
	HR (95% CI)	P value	HR (95% CI)	P value*
Genotype
AB	1		1
AA	2.27 (1.21 to 4.25)	0.01	2.58 (1.31 to 5.10)	0.006
BB	1.99 (1.12 to 3.55)	0.02	1.93 (1.04 to 3.58)	0.03
Genotype
AB	1		1
AA or BB	2.10 (1.28 to 3.47)	0.004	2.16 (1.26 to 3.78)	0.005
Centromere–telomere genotype
cA/tB or cB/tA	1		1
cA/tA or cB/tB	2.18 (1.29 to 3.67)	0.003	2.26 (1.29 to 3.97)	0.005
Centromere genotype
Bx/cenA	1
AA	2.31 (1.08 to 4.95)	0.03	2.50 (1.02 to 6.14)	0.04

*Multivariate analysis includes age, gender and number of metastases as covariates for 12-month progression-free survival; p≤0.05 denotes statistical differences.

Bx, X can be A or B haplotype; cA, centromeric motif A haplotype; cB, centromeric motif B haplotype; p-values in bold, indicate those that are lower than 0.05; tA, telomeric motif A haplotype; tB, telomeric motif of B haplotype.