Table 2.

Multivariate analysis (dependent variable: TPS, independent variables: age, gender, primary, metastatic sites, subtypes)

TPS <50% (reference) vs TPS ≥50%
Variables	All subtypes		Non-squamous NSCLC		LUSC
	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Age
<50 years	Reference	0.737	Reference	0.711	Reference	0.046*
≥50 years	0.97 (0.82 to 1.15)		1.03 (0.86 to 1.24)		0.61 (0.37 to 0.99)
Gender
Male	Reference	0.027*	Reference	0.184	Reference	0.015*
Female	1.08 (1.01 to 1.16)		1.05 (0.98 to 1.14)		1.23 (1.04 to 1.44)
Bx site
Primary	Reference	<0.001*	Reference	<0.001*	Reference	0.197
Metastatic	1.28 (1.19 to 1.37)		1.37 (1.27 to 1.49)		0.89 (0.74 to 1.06)
Primary (reference) vs metastatic site
Lymph node	1.58 (1.43 to 1.74)	<0.001*	1.80 (1.61 to 2.00)	<0.001*	0.83 (0.63 to 1.08)	0.163
Liver	0.98 (0.83 to 1.16)	0.835	1.03 (0.86 to 1.24)	0.75	1.21 (0.79 to 1.87)	0.385
Brain	1.00 (0.85 to 1.18)	0.994	1.02 (0.85 to 1.21)	0.842	0.96 (0.51 to 1.81)	0.903
Pleural fluid	1.48 (1.23 to 1.78)	<0.001*	1.53 (1.27 to 1.84)	<0.001*	0 (0 to 3.24e+166)	0.95
Soft tissue	1.30 (1.08 to 1.58)	0.007*	1.44 (1.17 to 1.79)	0.001*	0.92 (0.58 to 1.47)	0.73
Bone	0.83 (0.67 to 1.04)	0.101	0.81 (0.64 to 1.02)	0.073	0.87 (0.45 to 1.69)	0.684
Pleura	1.12 (0.89 to 1.40)	0.343	1.14 (0.89 to 1.45)	0.288	0.83 (0.39 to 1.77)	0.628
Adrenal gland	1.70 (1.30 to 2.22)	<0.001*	1.66 (1.24 to 2.21)	0.001*	2.04 (0.87 to 4.76)	0.1

*p < 0.05

LUSC, lung squamous cell carcinoma; NSCLC, non-small cell lung cancer; TPS, tumor proportion score.