Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 29;12:636485. doi: 10.3389/fphys.2021.636485

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Chen, Huang, Bai, Liu, Ma, Li, Lu, Fu, Fang, Li and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Effect of Allicin on the I_Na,L of the ΔKPQ-SCN5A mutation. (A,B) Representative current traces recorded. I_Na,L of ΔKPQ-SCN5A was significantly larger than that of WT, which was inhibited by Allicin. (C) Current densities of the I_Na,L in four groups were shown. I_Na,L of ΔKPQ-SCN5A was decreased by 30 μM Allicin from 1.92 ± 0.12 to 0.65 ± 0.03 pA/pF. (D) Time course of the I_Na,L of ΔKPQ-SCN5A inhibition by 30 μM Allicin and washout effect (n = 15). **P < 0.01 vs. WT group; ^##P < 0.01 vs. ΔKPQ group.