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. 2021 Mar 29;12:636485. doi: 10.3389/fphys.2021.636485

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Copyright © 2021 Chen, Huang, Bai, Liu, Ma, Li, Lu, Fu, Fang, Li and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of Allicin on current–voltage and concentration dependence on the I_Na,L of the ΔKPQ-SCN5A mutation. (A) Representative current–voltage relationship (voltage dependence) of the I_Na,L for the ΔKPQ-SCN5A mutation. (B) The effect of Allicin on concentration–response relationship on the I_Na,L of the KPQ-SCN5A mutation. IC₅₀: 28.58 μM (95% CI: 20.35–39.27 μM, n = 15).