Table 3.
Multivariable-Adjusted HRs for All-Cause Mortality and Cardiovascular Events by Baseline Serum Magnesium Levels in the Chronic Renal Insufficiency Cohort Study
| Unadjusted Model | Adjusted Modela | |
|---|---|---|
| Hazard Ratio (95% CI), P | Hazard Ratio (95% CI), P | |
| All-cause mortality (reference: tertile 2; magnesium 1.9-2.1) | ||
| Tertile 1b | 1.18 (0.97-1.42), 0.09 | 1.21 (0.99-1.48), 0.06 |
| Tertile 3 | 1.33 (1.10-1.60), 0.003c | 1.17 (0.96-1.42), 0.12 |
| Composite cardiovascular eventsd (reference: tertile 2; magnesium 1.9-2.1) | ||
| Tertile 1 | 1.16 (0.95-1.42), 0.14 | 1.11 (0.90-1.38), 0.32 |
| Tertile 3 | 1.18 (0.97-1.45), 0.11 | 1.07 (0.86-1.33), 0.55 |
| Incident myocardial infarction (reference: tertile 2; magnesium 1.9-2.1) | ||
| Tertile 1 | 1.25 (0.89-1.75), 0.19 | 1.17 (0.82-1.66), 0.39 |
| Tertile 3 | 0.94 (0.85-1.36), 0 .75 | 0.92 (0.63-1.36), 0.69 |
| Incident congestive heart failure (reference: tertile 2; magnesium 1.9-2.1) | ||
| Tertile 1 | 1.28 (0.96-1.72), 0.09 | 1.15 (0.84-1.57), 0.40 |
| Tertile 3 | 1.43 (1.06-1.91), 0.02c | 1.20 (0.88-1.64), 0.26 |
| Incident atrial fibrillation (reference: tertile 2; magnesium 1.9-2.1) | ||
| Tertile 1 | 1.36 (1.03-1.80), 0.03c | 1.36 (1.01-1.82), 0.04c |
| Tertile 3 | 1.47 (1.11-1.95), 0.007c | 1.27 (0.95-1.70), 0.10 |
a
Models adjusted for age, sex, race, clinical center, diabetes status, estimated glomerular filtration rate, 24-hour urinary protein excretion, and baseline cardiovascular, systolic blood pressure, and antihypertensive medications.
b
The distribution of magnesium by tertiles was tertile 1, 0.70 to 1.89 mg/dL; tertile 2, 1.90 to 2.09 mg/dL (reference group); and tertile 3, 2.10 to 3.30 mg/dL.
c
Statistically significant.
d
Composite cardiovascular events include incident congestive heart failure, myocardial infarction, stroke, and peripheral arterial disease.