. 2021 Mar 29;12:598708. doi: 10.3389/fphar.2021.598708

TABLE 5.

Clinical characteristics of the unrecovered patients. The unrecovered parameters are marked with an asterisk (*). ECG, electrocardiogram; Echo, echocardiography; DNR, daunorubicin; M, male; F, female; LR, low risk; IR, intermediate risk; IRBBB, incomplete right bundle branch block; PAH, pulmonary arterial hypertension.

No.	Age (year)	Risk	Occurrence course	ECG	Echo	Biochemical markers	Genes	DNR (mg/m²)
1	1–10	IR	Consolidation treatment	ST-T changes	*Pericardial effusion	Normal	SLC28A3:GA	175
1	1–10	IR	Consolidation treatment	ST-T changes	*Pericardial effusion	Normal	UGT1A6:GG	175
2	1–10	LR	Continuation treatment	ST-T changes	*PAH	Normal	SLC28A3:GG	75
2	1–10	LR	Continuation treatment	ST-T changes	*PAH	Normal	UGT1A6:GT	75
3	1–10	LR	Induction remission	*IRBBB	Normal	Normal	SLC28A3:GG	75
3	1–10	LR	Induction remission	*IRBBB	Normal	Normal	UGT1A6:GT	75
4	1–10	LR	Second induction	*T wave changes	Normal	Normal	SLC28A3:GG	75
4	1–10	LR	Second induction	*T wave changes	Normal	Normal	UGT1A6:GT	75
5	10–14	IR	Reinduction treatment	*QTc prolongation	Normal	Normal	SLC28A3:GG	175
5	10–14	IR	Reinduction treatment	*QTc prolongation	Normal	Normal	UGT1A6:GG	175
6	1–10	LR	Consolidation treatment	*IRBBB	Normal	Normal	SLC28A3:GG	75
6	1–10	LR	Consolidation treatment	*IRBBB	Normal	Normal	UGT1A6:GG	75
7	1–10	IR	Continuation treatment	*Sinus tachycardia	Normal	Normal	SLC28A3:GG	175
7	1–10	IR	Continuation treatment	*Sinus tachycardia	Normal	Normal	UGT1A6:GG	175

Bold values indicates of the SLC28A3 GA genotype (indicating a low risk of cardiotoxicity) and UGT1A6 GT genotype (indicating a high risk of cardiotoxicity).