TABLE 2.

Description of population, intervention, comparator, outcome and study design (PICOS).

Population	•Normal and cancer cell lines
	•Healthy and tumor bearing animals
Intervention	•Naringin
Comparison	•∆-changes between treatments (naringin/control/anticancer drug)
Outcome	•Effect of naringin on cancer cell growth inhibition and/or reduction of tumor size and volume
Study design	•In vitro studies
	•In vivo studies