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. 2021 Mar 29;12:635814. doi: 10.3389/fgene.2021.635814

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Copyright © 2021 Del Prete, Facchiano, Profumo, Angelini and Romano.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PC1vsPC2 and PC1vsPC3 plots for Case Study 1 (ovarian cancer). The PCA analysis of the feature matrix revealed that PC1, PC2, PC3 accounted for 54% of the total explained variance. (A) Shows the projection in the PC1 versus PC2 space, (B) the projection in the PC1 versus PC3 space. Samples are colored according to their group. Ovarian cancer groups (A, B) are overlapping, whilst control groups (C, D) are not clearly overlapping, because group D is widespread.