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. 2021 Mar;10(3):1410–1431. doi: 10.21037/tau-20-592

Table 1. Overview of the potential impact of genetic variation in micronutrient metabolism on male fertility.

Micronutrient Gene and SNP Impact
Retinoic Acid BCMO1: rs11645428 (11) Meiosis I/II and post meiotic spermatid development (12,13)
Vitamin B12 FUT2: rs602662 (14) Sperm count, quality and motility (15)
Vitamin C GSTT1: insertion or deletion (16) Semen volume, concentration, sperm count, morphology and motility (17)
Vitamin D CYP2R1: rs10741657 (18); GC: rs2282679 (18,19) Sperm motility and morphology (20); sex hormone binding globulin (SHBG) (21)
Vitamin E CYP4F2: rs2108622 (22); SCARB1: rs11057830 (22); APOA5: rs12272004 (22) Acrosome reaction (23); sperm morphology (24)
Folate MTHFR: rs1801133 (25) Sperm density and morphology (26)
Choline CHDH: rs12676 (27,28); PEMT: rs4646343 (29); PEMT: rs7946 (29) Sperm motility (27,28)
Betaine CHDH +432: rs12676 (30); PEMT -744: rs12325817 (30) Spermatogenesis (31)
Iron TMPRSS6: rs4820268 (32); TFR2: rs7385804 (33); HFE: rs1800562 (34); SLC17A1: rs17342717 (35); HFE: rs1799945 (34); TF: rs3811647 (34) Spermatogenesis (36); sperm volume, density, motility and morphology (37); excess leads to oxidative DNA damage (38)
Calcium GC: rs7041 (39); GC: rs4588 (39) Sperm maturation (40), motility (41), morphology (42), and overall function (43,44)