Table 1. Loop diuretic dosing comparison (11,13).
Characteristics | Furosemide (Lasix) | Torsemide | Bumetanide | Ethacrynic acid |
---|---|---|---|---|
Half life (hours) | 1.5–2.0 | 3.0–4.0 | 1.0–1.5 | 1.0 |
Bioavailability (%) | 10–100 | 80–100 | 80–100 | 100 |
Initial oral dosing (mg) | 20.0–40.0 | 10.0–20.0 | 0.5–1.0 | 50.0 |
Relative potency | 40 | 10–20 | 1 | NA |
IV to oral dosing | 1:2 | 1:1 | 1:1 | 1:1 |
Maximum dosing in 24 hours (mg) | 600 | 200 | 10 | 200 |
Duration of effect (hours) | ~6 | 6–16 | 4–6 | ~6–8 |
IV, intravenous.