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ROC curves of serum tumor biomarkers in diagnosing benign or malignant SPNs. ROC, receiver operating characteristic; CTC, circulating tumor cell; CEA, carcinoembryonic antigen; CA125, carbohydrate antigen 125; CA724, carbohydrate antigen 724; CYFRA21-1, cytokeratin fragment 21-1; NSE, neuron-specific enolase.
