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. 2021 Mar;9(6):507. doi: 10.21037/atm-21-392

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2021 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Workflow of NIR fluorescence imaging for patients with HNSCC. Patients were enrolled in two cohorts: intravenous injection of ICG and peritumoral injection of ICG. After ICG was given, NIR fluorescence imaging was performed in the cervical region, and fluorescence-positive LNs were sent for frozen section intraoperatively. After the fluorescence intensity was recorded, all LNs were sent to undergo paraffin section. NIR, near-infrared; HNSCC, head and neck squamous cell carcinoma; ICG, indocyanine green; LNs, lymph nodes.