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The JAK/STAT and PPAR signaling pathways are upregulated in both medial and atherosclerotic calcification.A and B, upregulated KEGG signaling pathways in CKD (A) and aged ApoE KO (B) mice. C and D, heat maps of selected upregulated genes in the JAK/STAT and PPAR signaling pathways in (C) CKD and (D) aged ApoE KO mice. Each point represents the log2 FPKM (fragments per kilobase per million) mapped fragments value of the indicated gene.
