Table 2.

Safety of Fecal Microbiota Transplatation in High-Risk Patients

Participants	Article types	Adverse events
Immunocompromised host	Systematic review (303 patients) [13]	Deaths (n=2), Colectomy (n=2), Bacteremia or infection (n=5), hospitalization (n=10), unspecificed life threatening complica- tion (n=7), flare-up of IBD (n=7)
Ulcerative colitis (mild to moderate)	Meta-analysis (4 studies, 277 patients) [18]	Serious adverse events: 7% of FMT participants vs. 5% of controls (RR, 1.4; 95% CI, 0.5-3.6)
	Meta-analysis (11 studies) [20]	Overall adverse events (95% CI): 36.9% (21.5–55.6)
Crohn’s disease	Meta-analysis (3 studies) [20]	Overall adverse events (95% CI): 5.8% (1.2–23.5)
Solid-organ transplantation recipients	Retrospective study (94 patients) [19]	Overall FMT related adverse events: 22.3%
		Serious FMT related adverse events: 3.2%

CI, confidence interval; IBD, inflammatory bowel disease; FMT, fecal microbiota transplantation; RR, relative risk