Table 5.
Mass Spectrometry statistical summary: - LME results, Cohen's d values and effect sizes for the DS compared with control cohort. Effect sizes were interpreted as small (Cohen's d absolute value ≤ 0.4), medium (0.5–0.7) and large (≥0.8) (Cohen, 1988). N-acetylaspartate (NAA), Creatine, Choline and Myo-inositol (mIns).
| Metabolites | Estimate | Standard error | df | t value | p value | Cohen's d |
|---|---|---|---|---|---|---|
| mIns | −370.8 | 170.37 | 41 | −2.18 | 0.04⁎ | −0.7 |
| NAA | 8.15 | 7.03 | 41 | 1.16 | 0.25 | 0.4 |
| Choline | 7.81 | 5.31 | 41 | 1.47 | 0.15 | 0.5 |
| Creatine | 106.07 | 64.83 | 41 | 1.64 | 0.11 | 0.5 |
⁎
Significant result, p < 0.05.