Table 3.

ABRs (second 6-mo study period; FAS and PPAS)

	FAS (N = 115)		PPAS (N = 95)
	FVIII trough level 1% to 3% (n = 57)	FVIII trough level 8% to 12% (n = 53)*	FVIII trough level 1% to 3% (n = 52)	FVIII trough level 8% to 12% (n = 43)
Total ABR
Mean (SD)	3.6 (7.5)	1.6 (3.4)	2.8 (3.0)	1.2 (2.4)
Median (Q1 to Q3)	2.0 (0.0-4.0)	0.0 (0.0-2.0)	2.0 (0.0-4.0)	0.0 (0.0-2.0)
Spontaneous ABR
Mean (SD)	2.5 (6.6)	0.7 (1.7)	1.7 (2.5)	0.6 (1.5)
Median (Q1 to Q3)	0.0 (0.0-4.0)	0.0 (0.0-0.0)	0.0 (0.0-4.0)	0.0 (0.0-0.0)
Spontaneous joint ABR
Mean (SD)	2.0 (6.4)	0.5 (1.7)	1.2 (2.0)	0.4 (1.4)
Median (Q1 to Q3)	0.0 (0.0-2.0)	0.0 (0.0-0.0)	0.0 (0.0-2.0)	0.0 (0.0-0.0)
Joint ABR
Mean (SD)	2.6 (7.4)	1.1 (2.6)	1.8 (2.2)	0.8 (2.3)
Median (Q1 to Q3)	0.0 (0.0-2.0)	0.0 (0.0-0.0)	1.0 (0.0-3.0)	0.0 (0.0-0.0)
ABR of joints with ≥4 spontaneous bleeds in 6 consecutive months
Mean (SD)	1.0 (6.8)	0.4 (1.5)	0.1 (0.6)	0.2 (1.3)
Median (Q1 to Q3)	0.0 (0.0-0.0)	0.0 (0.0-0.0)	0.0 (0.0-0.0)	0.0 (0.0-0.0)
Injury-related ABR
Mean (SD)	1.1 (2.0)	0.9 (2.6)	1.1 (1.9)	0.7 (1.7)
Median (Q1 to Q3)	0.0 (0.0-2.0)	0.0 (0.0-0.0)	0.0 (0.0-2.0)	0.0 (0.0-0.0)

^*ABR based on 53 PwHA; data not available from 5 randomized PwHA who discontinued the study before the second 6-mo period.