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. 2021 Mar 13;11(11):5491–5510. doi: 10.7150/thno.55041

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Working model of miR-143/145 in regulating BMSCs stemness properties and osteoclast activity during progressive postmenopausal bone loss. By investigating links between progressive postmenopausal bone loss and impaired BMSCs function, miR-143/145 cooperates with MIR143HG to regulate BMSCs pluripotency genes by protecting gene translation and activating SOX2 transcription. Inhibition of miR-143/145 could improve bone formation and reduce bone resorption in estrogen-deficient osteoporosis.