Table 1.
The amount of Ce and Y-27632 in corneal, ciliary body, and retinal tissues of glaucomatous rabbit eyes treated with different drug-loaded HMCN formulations
| Sample code | Ce | Y-26732 | ||||
|---|---|---|---|---|---|---|
| Cornea (μg/g)a | Ciliary body (μg/g)b | Retina (ng/g)c | Cornea (μg/g)d | Ciliary body (μg/g)e | Retina (ng/g)f | |
| Y/CNP10nm | 4.5 ± 0.8 | 50.3 ± 1.7 | 246.7± 19.3 | 0.4 ± 0.2 | 1.3 ± 0.5 | 28.3 ± 9.3 |
| Y/CNP20nm | 2.7 ± 1.1g | 60.6 ± 2.4g | 153.1± 22.8g | 1.1 ± 0.2g | 14.6 ± 1.9g | 81.5 ± 11.2g |
| Y/CNP40nm | 1.8 ± 0.9g | 69.1 ± 3.0g | 92.0 ± 27.0g | 0.2 ± 0.1 | 1.8 ± 0.7 | 32.6 ± 7.4 |
a: Inductively coupled plasma mass spectrometry was employed to quantify the amount of ceria in the corneal tissues of test rabbit eyes. Data are expressed as mean ± SD (n = 6); b: Inductively coupled plasma mass spectrometry was employed to quantify the amount of ceria in the ciliary body tissues of test rabbit eyes. Data are expressed as mean ± SD (n = 6); c: Inductively coupled plasma mass spectrometry was employed to quantify the amount of ceria in the retinal tissues of test rabbit eyes. Data are expressed as mean ± SD (n = 6); d: High performance liquid chromatography was used to determine the amount of Y-27632 in the corneal tissues of test rabbit eyes. Data are expressed as mean ± SD (n = 6); e: High performance liquid chromatography was used to determine the amount of Y-27632 in the ciliary body tissues of test rabbit eyes. Data are expressed as mean ± SD (n = 6); f: High performance liquid chromatography was used to determine the amount of Y-27632 in the retinal tissues of test rabbit eyes. Data are expressed as mean ± SD (n = 6); g: Significant difference as compared to the CNP10nm groups (P < 0.05).