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. 2021 Mar 20;11(11):5605–5619. doi: 10.7150/thno.55878

Figure 6.

Figure 6

Inhibition of HDAC1/2 alleviated diet-induced atherosclerotic lesion development in Apoe-/- mice. Apoe-/- male mice were i.p. injected with Romi (2 mg/kg body weight) or PBS (ctrl) and fed with a high-fat diet for 12 weeks followed by VCAM-1 and GATA6 expression in the thoracic abdominal artery analyzed with Western Blotting and (B-E) atherosclerosis characterized. (B) En face staining of lesion areas with Oil Red O in thoracic-abdominal aorta (TA) (n = 8). (C) Cross-sections of aortic sinuses were stained with Oil Red O for intimal area and lipid deposition (n = 8). (D-E) Longitudinal sections of aortic arches were stained with Oil Red O (D) or immunostained for macrophages (Mφ) with anti-Mac-3 antibody (E) (n = 8). Shown right are representative photographs. *p < 0.05; p < 0.01; one sample t-test (A); two-tailed paired t-test (B, C, E) and one-tailed paired t-test (D).