Table 4.
Characterization of lipid-based nanoparticles
| Investigators | Nanoparticles (NPs) |
Average particle size (nm)(±S.D.) | Zeta potential (mV)(±S.D.) |
Entrapment efficiency (EE%) | Drug loading (DL%) |
Drug release % |
PDI |
|---|---|---|---|---|---|---|---|
| Bondi et al. 71 | NLC-A NLC-B |
221.0 219.0 |
-17.2 -18.9 |
100.00 58.52 |
18.46 10.30 |
79.8(24h) 50.5(24h) |
0.512 0.417 |
| Grillone et al. 67 | Sor-Mag-SLNs | 248 (± 113) | -23.0(±5.3) | -- | -- | -- | 0.2(±0.1) |
| Yao et al. 122 | CMCS-SiSf-CL | 200.1(±7.9) | -10.6(±1.0) | 90.36(±0.63) | 5.19(±0.035) | 26(pH=7.4) 30(pH=6.5) |
0.199(±0.31) |
| Xiao et al. 86 | SF/Gd-liposomes | 180(±1) | -7.0(±1.0) | 96 (± 2) | 4.3 (± 0.1) | -- | 0.20 |
| Yang et al. 65 | Sorafenib-LNS | 164.5(±4.5) | -11.0(±0.28) | -- | 10.55(± 0.16) | -- | 0.202(±0.015) |
| Zhang et al. 66 | HA/SF- cLNS | 130.57(±14.06) | -18.1(±1.1) | -- | 6.8(±0.1) | 33.64(72h) | 0.261(± 0.004) |
| Benizric et al. 68 | SLNs+/- | Nuclei+=304.4 Nuclei-=335.2 |
SLN+=+59.1 SLN-=-54.9 |
55-75 | 50 | -- | Nuclei+=0.289 Nuclei-=0.202 |
| Duan et al. 189 | NAcGal-DOX/SOR LNPs | 121.2(±3.5) | -37.4(±3.6) | 83.2(±3.3) | 4.1(±0.4) | 70-80(48h) | 0.16(±0.03) |
| Liu et al. 211 | LCPP NPs | 102.9(±7.4) | +6.1(±3.5) | 93(±6) | -- | -- | 0.326(±0.04) |
| Zhao et al. 153 | miR-375/Sf-LCC NPs | 100.7(±12.1) | +40.37 (±3.38) | -- | 35.2 (±8.7) | ≈40(pH=7.4) ≈72(pH=6.8) |
0.116 (±0.03) |
| Mu et al. 212 | GSI-Lip | 100-150 | -10-0 | 92.44 (±1.60) | -- | ≈80(48h) | 0.1-0.2 |
| Tunki et al. 69 | GAL-SSLN | 111.00 (±6.99) | -19.8 (±1.11) | 95 (±1.8) | -- | 40-50(48h) | 0.354 (±0.024) |
| Wang et al. 186 | CMCS/SF-CLN CMCS/m-IMD-CLN |
117.9(±3.4) 129.4(±6.8) |
-21.1(±2.5) -25.5(±0.8) |
-- -- |
5.22 (±0.25) 7.43 (±0.51) |
-- -- |
0.277(±0.010) 0.291(±0.003) |
| Wang et al. 135 | LD-SDN | 126.5 (±1.33) | -25 | 94.5 (±1.62) | 13.5 (±0.85) | 36-38(24h) 70-80(60h) |
0.135 |
| Wang et al. 140 | G-S27LN | ≈165 | +25 | 93.2 (±1.68) | ≈8.95 | 38(pH=7.4) 76(pH=5.0) |
≈0.115 |
| Younis et al. 137 | MK-siRNA/PEI core STR-R8-NPs SP94-NPs |
56 (±8) 180 (±11.2) 150 (±9.4) |
-8.5 (±3.55) +49 (±6.5) -10.5 (±3.75) |
-- 90 (±8.25) 91.5 (±9.8) |
-- -- -- |
-- -- -- |
0.270 (±0.045) 0.332 (±0.061) 0.205 (±0.035) |
| Zhang et al. 129 | DOX+SOR/iRGD NPs | 126.3(±16.4) | - 21.4(±4.6) | 70.8(±2.8) | 3.6(±0.05) | -- | 0.105(±0.016) |