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Signaling pathways of the serotonin receptor (5-HTR) subtypes. Serotonin signals through 15 receptor subtypes. Most of the receptors belong to GPCRs except the 5-HTR3 subfamily. These receptors activate four major interconnected signaling networks: PI3K/Akt, PKC/Ca2+, MAPK, and PKA-cAMP axis. Here, solid black arrows indicate stimulation of a pathway and black dashed arrows indicate inhibition of a pathway.
