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Effects of serotonin signaling on cancer. Serotonin signaling promotes tumor progression by stimulating proliferation and inhibiting apoptosis of cancer cells via MAPK and PI3K/Akt signaling axis. Here, solid black arrows indicate stimulation and dashed black arrows indicate inhibition. Abbreviations: BC, Breast cancer; CC, Colon cancer; HCC, Hepatocellular carcinoma; PC, Prostate cancer.
