Table 1.
Effects of serotonin receptor agonists in different immune cells
| Agonists | Receptors | Functions | References | ||||
|---|---|---|---|---|---|---|---|
| DC | Macrophage | T cells | NK cells | B Cells | |||
| S14506 | 5-HTR1A | -- | -- | Suppresses the rise of intracellular cAMP level in response to ATP | -- | -- | 133, 134 |
| 8-OH-DPAT | 5-HTR1A/7 | Enhances dose dependant secretion of IL-8 and IL-1β and suppressed IL-12 and TNF-α release from mature DCs. | -- | -- | Increases NK Cell cytotoxicity. | Increases proliferation of B cells, characterised by [3H] thymidine uptake and S phase transition. | 38, 48, 75 |
| (+)ALK | 5-HTR1A | -- | -- | -- | a) Stimulates NK cell mediated killing of NK insensitive Daudi cells in the presence of IL-1, TNF-α and monocyte b) Increases IFN-γ secretion in the presence of IL-2. |
-- | 49, 52 |
| AnHCL | 5-HTR1B | Stimulates intracellular Ca2+ spike in immature DCs. | -- | -- | -- | -- | 38 |
| BRL5443 | 5-HTR1E/1F | Stimulates intracellular Ca2+ spike in immature DCs. | -- | -- | -- | -- | 38 |
| DOI | 5-HTR2 | Stimulates intracellular Ca2+ spike in immature DCs. | -- | Inhibits TNF-α production from PBMC. | -- | -- | 38, 60 |
| BW-723C86 | 5-HTR2B | -- | a) Stimulates M2 macrophage polarization by signalling through the ERK pathway b) Inhibits LPS stimulated TNF-α production through the NFκB pathway and stimulates LPS stimulated CCL2 production from monocyte-derived macrophage thus imparts anti-inflammatory effect through AhR activation. |
-- | -- | -- | 31, 30 |
| 2-Methyl- Serotonin | 5-HTR3 | Enhances dose dependant secretion of IL-8 and IL-1β and suppresses IL-12 and TNF-α release from mature DCs. | -- | Activates T cells via increasing intracellular Na+ and thus helping the progression of T cell from S phase to G2/M phase. | -- | -- | 38, 65 |
| 2MHT | 5-HTR4 | Enhances dose dependant secretion of IL-8 and IL-1β and suppresses IL-12 and TNF-α release from mature DCs. | -- | -- | -- | -- | 38 |
| 5-CI | 5-HT1/4/7 | Enhances dose dependant secretion of IL-8 and IL-1β and suppresses IL-12 and TNF-α release from mature DCs. | -- | -- | -- | -- | 38 |
| AS19 | 5-HTR7 | -- | a) Enhances the expression of PDE2A and THBS1 through PKA-cAMP axis and thus promotes anti-inflammatory gene profile. b) Mimics the effect of 5-HT mediated downregulation of TNF-α and IL-12p40 secretion. |
Stimulates T cell proliferation alike 5-HT. | -- | -- | 13, 66 |