Table 2.
Effects of serotonin receptor antagonists on immune cells
| Antagonists | Receptors | Functions | ||||
|---|---|---|---|---|---|---|
| DC | Macrophage | T cells | B cells | References | ||
| (+) WAY 100135 | 5-HTR1A | -- | -- | -- | Inhibits the proliferative effect of serotonin on B cells. | 75 |
| Methylseride, ketanserin | 5-HTR2 | Abolishes the 5-HT-mediated intracellular Ca2+ spike in immature DCs. | -- | a) Inhibits the capabilities of T cells to generate delayed type of hypersensitivity. b) Abolishes the 5-HT-mediated reduction in IL-1β secretion in PBMC. |
-- | 38, 60, 67 |
| SB-204741 | 5-HTR2B | -- | a) Inhibits M2 macrophage specific gene (STAB1 & SERPINB2) expression. b) Reduces the expression of MMP12 and enhances the CD1B mRNA expression. |
-- | -- | 30 |
| RS-39604 | 5-HTR4 | Inhibits the LPS mediated IL-8 and IL-1β release through 5-HTR4 stimulation from immature DCs. | -- | -- | -- | 38 |
| SB-269970, SB-258719 | 5-HTR7 | a) Inhibits the LPS mediated IL-8 and IL-1β release through 5-HTR7 stimulation from immature DCs. b) Abolishes the increase in the length of processes of mature DCs by 5-HTR7 agonism. |
a) Inhibits 5-HT mediated upregulation of TGFβ1 mRNA in monocyte-derived macrophages. b) Dampens the effect of 5-HT on limitation of expression of type I IFN responsive gene via PKA-cAMP axis. c) Reverses the 5-HT mediated inhibitory effect on LPS-stimulated TNF-α and IL-12p40 release from monocyte-derived macrophage. d) Dampens the 5-HT-mediated upregulation of M2 macrophage specific gene expression (SERPINB2, THBSI, and COL23AI). |
Inhibits 5-HT mediated phosphorylation of the ERK1/2 and Iκβα in T cells. | -- | 13, 30, 38, 40, 66, 30 |