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. 2021 Mar 13;11(11):5525–5538. doi: 10.7150/thno.57510

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In vitro characterization of auristatin F NDCs. A) Binding assay and B) Cytotoxicity assay (5 days incubation) of 11A4-Mal-AF (yellow filled squares), 11A4-ABD-mal-AF (green filled circles), 11A4-Lx-AF (brown open squares) and 11A4-ABD-Lx-AF (black open circles) drug conjugates on HER2-positive cells BT-474 and NCI-N87 cells or HER2-negative MDA-MB-231 cells. Values plotted as mean ± SD (n = 3). The tables display K_D and IC₅₀ (mean ± SD) as calculated from the graphs in A) and B) respectively.