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. 2021 Mar 13;11(11):5525–5538. doi: 10.7150/thno.57510

Figure 5.

Figure 5

Therapeutic efficacy of auristatin F NDCs in NCI-N87 tumor bearing mice. Nude mice bearing NCI-N87 tumors in both flanks received a single bolus injection of NDCs with DAR of 1.0 at a dose of 250 nmol/kg. A) Schematic representation of the therapeutic efficacy study. B) Relative tumor volume, expressed as mean ± SD, was measured twice a week for 124 days; and C) Kaplan-Meier survival curves of mice injected with 11A4-mal-AF (yellow filled squares, n = 8), 11A4-ABD-mal-AF (green filled circles, n = 8), 11A4-Lx-AF (brown open squares, n = 8) and 11A4-ABD-Lx-AF (green open circles, n = 8) or PBS (black diamonds, n = 8) at day 0. For representation purposes, tumor size of a given group was not included in the graph anymore when animal drop-out was more than 50%. Size of individual tumors can be found in Supplementary Figure S11.