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. 2021 Mar 11;11(11):5346–5364. doi: 10.7150/thno.58385

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Characteristics of differentially methylated regions. (A) Circular plot of 4,410 hypermethylated (hyperMe) and 4,824 hypomethylated (hypoMe) differentially methylated regions (DMRs). ESCs, embryonic stem cells. (B) Distribution of hyperMe-DMRs and hypoMe-DMRs within the region of 15 chromatin states defined in ESCs. Definitions of 15 chromatin states are shown in Figure 2C. (C) Definitions of 15 chromatin states and histone mark probabilities. (D) Enrichments of DMRs in ESCs, IMR90, NHLF, lung tissues, and A549 cells across 15 chromatin states.