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. 2021 Mar 11;11(11):5346–5364. doi: 10.7150/thno.58385

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HyperMe-DMRs are recurrently hypermethylated. (A) Methylation levels of total hyperMe-DMRs between tumor and normal samples across 21 cancer types. Data are shown as mean ± SD. The top digits signified number of tumor (red) and normal (green) samples analyzed. (B) Methylation levels of total hyperMe-DMRs and the other set of hyperMe-DMRs (i.e., ESC-poised and ESC-active promoter marked hyperMe-DMRs) across tissues, cell types and cancer cell lines. Data are shown as mean ± SD. The top digits signified number of tissues/cells.