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. 2021 Mar 11;11(11):5346–5364. doi: 10.7150/thno.58385

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Functional characterization of hyperMe-DMRs subtypes. (A) Examples of two hyperMe-DMRs subtypes, one is pre-marked by poised promoter (IRX1, poised-hyperMe DMRs) and the other by active promoter (MAPK7, active-hyperMe DMRs) in ESCs. Annotations of chromatin state across 127 reference epigenomes including ESCs and lung-related tissues/cells are shown. (B) Fraction of no/bottom-expression genes for all annotated genes and genes harboring poised-hyperMe DMRs and active-hyperMe DMRs in their promoters. (C) Distribution of no differential expression, upregulation and downregulation for genes harboring poised-hyperMe DMRs and active-hyperMe DMRs in their promoters.