Figure 8.

Expression of epigenetically dysregulated genes is affected by methylation changes of transcription factor binding motifs in lung cancer. (A, B) Activity plot integrating the correlation between methylation of transcription factor binding motifs and expressional fold changes of targeted methylation-driven genes. The strength of inactivation (red; A) and activation (blue; B) in tumors compared to normal samples is represented by color and intensity. (C) Correlation between methylation level of two CpG sites within the EGR1 binding motif of TCF21 and expression level of TCF21. Genomic coordinates of the EGR1 binding motif relative to TCF21 are shown in the top panel. (D) Correlation between EGR1 and TCF21 expression.