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. Author manuscript; available in PMC: 2022 Mar 1.
Published in final edited form as: Matrix Biol. 2021 Jan 14;97:40–57. doi: 10.1016/j.matbio.2021.01.002

Fig. 9.

Fig. 9.

HA-versican pericellular matrix functions as an essential niche for Flk1+ cells. Model depicting the chronology of versican and HA expression and proposed functions in murine extraembryonic mesoderm during vasculogenesis and hematopoiesis. The present work localizes HA-versican to the pericellular matrix of Flk1+ cells, but not the downstream CD41+ committed progenitors or to other CD31 vascular endothelial cells. The inset box proposes that the negatively charged HA-versican pericellular matrix sequesters pro-vasculogenic factors such as VEGF and Ihh.