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. 2021 Mar 19;12(4):625–630. doi: 10.1021/acsmedchemlett.1c00024

Table 2. Cytotoxicity of Verticillin A (1), Verticillin H (2), and Related Analogues (4–13).

  IC50 (nM)a
compound MDA-MB-231 OVCAR3 MDA-MB-435
verticillin A (1) 23 36 18
verticillin H (2) 31 229 44
4 21 96 41
5 17 25 19
6 12 105 24
7 20 72 21
8 13 133 21
9 7 137 11
10 49 79 31
11 21 68 22
12 12 19 9
13 12 33 9
taxol (control) 0.6 1.8 0.3
a

MDA-MB-435, human melanoma cancer cells; OVCAR3, human ovarian cancer cells; MDA-MB-231, human breast cancer cells.