Table 4. IC50 Values for COX-1 and COX-2 Enzymes.
| compound | IC50 COX-1 (μM) | IC50 COX-2 (μM) | selectivity index (COX-2/COX-1) |
|---|---|---|---|
| 3b | 1.57 ± 0.54 | 43.0 ± 10.3 | 27.4 |
| 3c | 1.89 ± 0.63 | 37.3 ± 9.36 | 19.7 |
| 3k | 1.90 ± 0.69 | 10.1 ± 1.38 | 5.32 |
| 3v | 3.14 ± 0.99 | >50 | COX-1-selective |
| 6c | 0.376 ± 0.189 | >50 | COX-1-selective |
| 6e | 0.142 ± 0.014 | >50 | COX-1-selective |
| 7o | 1.39 ± 0.72 | >50 | COX-1-selective |
| 8a | 0.78 ± 0.64 | >50 | COX-1-selective |
| 8b | 1.58 ± 0.89 | >50 | COX-1-selective |
| 9a | 0.141 ± 0.045 | >50 | COX-1-selective |
| 9b | 0.064 ± 0.044 | >50 | COX-1-selective |
| ibuprofen | 2.19 ± 0.78 | 3.30 ± 0.96 | 1.51 |
| SC-560 | 0.006 ± 0.003 | 1.03 ± 0.40 | 179.5 |