Skip to main content
. 2021 Mar 5;12(4):572–578. doi: 10.1021/acsmedchemlett.0c00571

Figure 4.

Figure 4

Compound 20 is a selective inhibitor of the TRPC subfamily. (a) Representative whole-cell recordings of HEK293 cells overexpressing hTRPA1, rTRPV1, rTRPV4, hTRPC3, mmTRPC6, hTRPC7, and hTRPM8. Currents were evoked with high concentrations of the agonist (red) and challenged with 20 (10 μM) in the presence of the respective agonist (blue). (b) Percentage of peak current blocked by 20 (10 μM) in the presence of each agonist. AITC, Allyl isothiocyanate; Cap, capsaicin; GSK101, GSK1016790A. Bars are mean ± SD. n is denoted above the x-axis.