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. 2021 Apr 15;13(4):216–222. doi: 10.4251/wjgo.v13.i4.216

Table 2.

Role of anthrax toxin receptor 1 in different kinds of cancer

Different kinds of cancer
Summary of findings
Ref.
Gastric cancer Overexpress in gastric adenocarcinoma Sotoudeh et al[11]
Active the PI3K/AKT/mTOR signaling pathway Cai et al[19]
It is the potent antigenic targets for CAR T cell therapy Sotoudeh et al[18]
Colorectal cancer Influence tumor development by disrupting tumor vasculature. Fernando et al[20]
It possible use as biomarkers for screening, diagnosis, and therapy Pietrzyk et al[21]
Lung cancer It regulates the proliferation, apoptosis, migration and invasion of lung cancer cells. Gong et al[22]
It is an excellent indicator for early clinical diagnosis and prognosis of lung cancer. Sun et al[23]
Breast cancer It enhances tumor immunity in conjunction with immunization against differentiation ag. Felicetti et al[24]
It expression in triple-negative breast cancer. Gutwein et al[25]
It enhances tumor growth and metastasis in breast cancer cells. Opoku-Darko et al[26]
ANTXR1-Specific CAR T cells as a targeted therapy for breast cancer. Byrd et al[27]