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. 2020 Jun 26;70(5):940–950. doi: 10.1136/gutjnl-2020-320853

Figure 3.

Figure 3

The MBOAT7 rs641738T variant associates with fibrosis independent of inflammation. Hepatic Mboat7 deficiency is not associated with altered free fatty acids in mice. (A, B) the frequency of the MBOAT7 rs641738C>T allele in NAFLD patients (A) BMI ≤35 (without inflammation, F0, n=215; without inflammation, F1–4, n=74; with inflammation, F0, n=10; with inflammation, F1–4, n=62) and (B) BMI >35 (without inflammation, F0, n=231; without inflammation, F1–4, n=96; with inflammation, F0, n=64; with inflammation, F1–4, n=94) from a cross-sectional liver biopsy cohort, stratified by the presence of liver fibrosis and lobular inflammation. Genetic analyses were calculated using an additive model. Differences between the groups were compared by logistic regression analysis adjusted for sex, age, BMI and presence of T2DM (online supplementary table 1 & 2). (C, D) hepatic free-fatty acid levels on normal diet (C) and HFCDD diet (D). Data are presented as mean±SEM. (n=6–8 mice). BMI, body mass index; HFCDD, high-fat, methionine-low, choline-deficient diet; MBOAT7, membrane-bound O-acyltransferase domain containing 7; NAFLD, non-alcoholic fatty liver disease; T2DM, Type 2 Diabetes mellitus; MAF, Minor allele frequency; SEM, SE of the mean.