Table 3.

Candidate prenyltransferases for naringenin prenylation. Eleven promiscuous microbial prenyltransferases (PTs) were selected for testing for prenylation of naringenin in yeast. A botanical naringenin PT, SfN8DT-1, was used as the positive control.

Source	Name	Species	in vitro Prenylation activity to flavonoids	Plenylation position of Naringenin	Reference
Plant	SfN8DT-1	Sophora flavescens	Naringenin (physiological substrate), Liquiritigenin, Hesperetin	C-8 of A-ring	Levisson et al. (2019), Li et al. (2015), Sasaki et al. (2008, 2009)
Actinomycetes	SCO7190	Streptomyces coelicolor A3 (2)	Naringenin	C-6 of A-ring	Kumano et al. (2008)
	NovQ	Actinoalloteichus cyanogriseus (Streptomyces niveus)	Naringenin, Apigenin, Daizein, Genistein	C-3′ and 4-O′ of B-ring	Ozaki et al. (2009)
	6-DMATS	Streptomyces ambofaciens	–	–	Winkelblech and Li (2014)
Fungi	5-DMATS	Aspergillus clavatus	–	–	Yu et al. (2012)
	7-DMATS	Aspergillus fumigatus	Naringenin, 7-hydroxyflavanone, Eriodictyol, Hesperetin, Silibinin, Phloretin, Apigenin, Genistein, Biochanin A	C-6 of A-ring	Kremer et al. (2007), Zhou et al. (2015)
	AnaPT	Neosartorya fischeri (Aspergillus fischeri)		C-3′ of A-ring	Yin et al. (2009), Zhou et al. (2015)
	CdpC3PT	N. fischeri (A. fischeri)	–	–	Yin et al. (2010)
	CdpNPT	A. fumigatus	–	–	Yin et al. (2007)
	FgaPT2	A. fumigatus	–	–	Unsöld and Li (2005)
	FtmPT1	A. fumigatus	–	–	Grundmann and Li (2005)