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. 2021 Mar 1;17(4):957–971. doi: 10.7150/ijbs.52591

Figure 4.

Figure 4

MiR-146a-5p targets PRSS1 and inhibits MGC803 cell growth and proliferation. (A) MiR-146a-5p expression was significantly decreased in GC cells. (B) PRSS1 mRNA expression was significantly increased in GC cells. (C) The expression level of miR-146a-5p was negatively correlated with PRSS1 mRNA expression as indicated by qRT-PCR. (D-E) The effects of MGC803 cells transfected with miR-146a-5p mimic or miR-146a-5p inhibitor on growth and colony-forming ability were determined by the MTT and colony forming assays. (F-G) Western blot and ICC analyses showed that miR-146a-5p mimic reduced PCNA protein expression while miR-146a-5p inhibitor increased PCNA expression. Data are shown as the means ± SD. *P<0.05, **P<0.01, ***P<0.001; #P<0.05, ###P<0.001.