Table 1.
Differentially expressed proteins during human gastric mucosa epithelial carcinogenesis
| No. | Accession# | Protein Name | AH vs. NGM | GPDAC vs. NGM | LMGAC vs. NGM | GPDAC vs. AH | LMGAC vs. AH | LMGAC vs. GPDAC |
|---|---|---|---|---|---|---|---|---|
| 1 | IPI00465084.6 | Desmin | ↓0.098 | ↓0.024 | ↓0.023 | ↓0.123 | ↓0.016 | |
| 2 | IPI00027720.1 | PnLIP Pancreatic triacylglycerol lipase precursor | ↓0.229 | ↓0.024 | ↓0.177 | ↓0.107 | ↓0.138 | |
| 3 | IPI00020987.1 | PRELP Prolargin precursor | ↓0.153 | ↓0.025 | ↓0.175 | ↓0.163 | ↓0.142 | |
| 4 | IPI00009826.2 | Carboxypeptidase B precursor | ↓0.087 | ↓0.027 | ↓0.063 | ↓0.253 | ↓0.425 | |
| 5 | IPI00025476.1 | AMY1B Pancreatic alpha-amylase precursor | ↓0.449 | ↓0.028 | ↓0.115 | ↓0.061 | ↓0.256 | ↓0.240 |
| 6 | IPI00878546.1 | Protein disulfide isomerase family A, member 2 | ↓0.065 | ↓0.030 | ↓0.093 | ↓0.461 | ↓0.322 | |
| 7 | IPI00009823.3 | Carboxypeptidase A1 precursor | ↓0.163 | ↓0.053 | ↓0.328 | ↓0.411 | ||
| 8 | IPI00021885.1 | FGA Isoform 1 of Fibrinogen alpha chain precursor | ↓0.316 | ↓0.069 | ↓0.131 | ↓0.219 | ↓0.413 | ↓0.530 |
| 9 | IPI00005924.4 | PnLIPRP2 pancreatic lipase-related protein 2 | ↓0.051 | ↓0.084 | ↓0.136 | ↓0.608 | ↓0.619 | |
| 10 | IPI00010796.1 | P4HB Protein disulfide-isomerase precursor | ↓0.175 | ↓0.089 | ↓0.506 | ↓0.637 | ||
| ... | ... | ... | ... | ... | ... | ... | ... | ... |
| 24 | IPI00218320.4 | TPM3 Isoform 3 of Tropomyosin alpha-3 chain | ↓0.205 | ↓0.608 | ↑1.047 | ↓0.581 | ||
| 25 | IPI00026271.5 | Ribosomal protein S14 | ↓0.174 | ↓0.223 | ↓0.555 | ↓0.402 | ||
| 26 | IPI00219217.3 | L-lactate dehydrogenase B chain | ↓0.119 | ↓0.227 | ↓0.134 | ↓0.421 | ↓0.319 | |
| 27 | IPI00515087.2 | chymotrypsinogen B2 | ↓0.550 | ↓0.236 | ↓0.525 | ↓0.429 | ↓0.449 | |
| 28 | IPI00298497.3 | Fibrinogen beta chain precursor | ↓0.363 | ↓0.240 | ↓0.402 | ↓0.661 | ↓0.343 | ↓0.597 |
| 29 | IPI00856098.1 | p180/ribosome receptor | ↓0.555 | ↓0.242 | ↓0.614 | ↓0.437 | ↓0.247 | ↓0.394 |
| 30 | IPI00298547.3 | PARK7 Protein DJ-1 | ↓0.192 | ↓0.249 | ↓0.324 | |||
| 31 | IPI00550991.3 | SERPINA3 | ↓0.242 | ↓0.250 | ↓0.154 | ↓0.329 | ↓0.131 | ↓0.234 |
| 32 | IPI00004457.3 | AOC3 Membrane copper amine oxidase | ↓0.214 | ↓0.261 | ↓0.429 | ↓0.242 | ↓0.256 | |
| 33 | IPI00218914.5 | Retinal dehydrogenase 1 | ↓0.182 | ↓0.268 | ↓0.343 | ↓0.238 | ↓0.237 | ↓0.207 |
| 34 | IPI00010133.3 | Coronin-1A | ↓0.353 | ↓0.281 | ↓0.586 | ↓0.510 | ↓0.167 | |
| 35 | IPI00015614.3 | PRSS3 Isoform A of Trypsin-3 precursor | ↓0.273 | ↓0.288 | ↓0.143 | ↑2.014 | ||
| ... | ... | ... | ... | ... | ... | ... | ... | ... |
| 190 | IPI00646304.4 | PPIB peptidylprolyl isomerase B precursor | ↑2.489 | ↑4.325 | ↑1.820 | ↑2.148 | ↑2.377 | |
| 191 | IPI00744692.1 | TALDO1 Transaldolase | ↑2.312 | ↑4.365 | ↑1.570 | ↑3.597 | ||
| 192 | IPI00414283.5 | fibronectin 1 isoform 4 preproprotein | ↑1.959 | ↑4.365 | ↑2.228 | ↑2.466 | ||
| 193 | IPI00398778.3 | PLEC1 plectin 1 isoform 10 | ↑1.871 | ↑4.406 | ↑10.765 | ↑7.586 | ||
| 194 | IPI00815665.1 | PRSS1 protein | ↑4.966 | ↑4.446 | ↑7.253 | ↑15.276 | ↑4.966 | ↑3.076 |
| 195 | IPI00218918.5 | Annexin A1 | ↑4.487 | ↑2.831 | ↑3.631 | |||
| 196 | IPI00021766.5 | RTN4 Isoform 1 of Reticulon-4 | ↑3.221 | ↑4.529 | ↑3.253 | ↑20.512 | ↑4.328 | ↑16.596 |
| 197 | IPI00215911.3 | APEX1 DNA-(apurinic or apyrimidinic site) lyase | ↑4.656 | ↑2.051 | ↑6.252 | ↑2.754 | ↑2.270 | |
| 198 | IPI00607708.3 | LDHA Isoform 2 of L-lactate dehydrogenase A chain | ↑6.918 | ↑4.656 | ↑12.134 | ↑10.375 | ||
| 199 | IPI00796333.1 | ALDOA 45 kDa protein | ↑6.026 | ↑4.742 | ↑2.786 | ↑1.939 | ↑5.861 | |
| 200 | IPI00025512.2 | Heat shock protein beta-1 | ↑2.208 | ↑4.786 | ↑4.831 | ↑4.487 | ||
| 201 | IPI00186711.3 | PLEC1 plectin 1 isoform 6 | ↑3.515 | ↑4.786 | ↑2.443 | ↑4.446 | ↑2.270 | ↑1.959 |
| 202 | IPI00021827.3 | DEFA3 Neutrophil defensin 3 precursor | ↑4.831 | ↑2.512 | ↑2.512 | ↑3.212 | ↑1.923 | |
| ... | ... | ... | ... | ... | ... | ... | ... | ... |
| 216 | IPI00218733.6 | Superoxide dismutase | ↑4.462 | ↑6.546 | ↑5.754 | ↑4.656 | ||
| 217 | IPI00219038.9 | H3F3B Histone H3.3 | ↑1.837 | ↑6.607 | ↑3.597 | |||
| 218 | IPI00000105.4 | Major vault protein | ↑4.128 | ↑6.855 | ↑2.629 | ↑4.699 | ↑4.207 | |
| 219 | IPI00465431.7 | LGALS3 Galectin-3 | ↑7.112 | ↑6.918 | ↑2.466 | ↑2.805 | ||
| 220 | IPI00414676.6 | Heat shock protein HSP 90 | ↑3.664 | ↑7.379 | ↑3.311 | ↑40.179 | ↑18.030 | ↑2.228 |
| 221 | IPI00019502.3 | Myosin-9 | ↑4.525 | ↑7.586 | ↑3.342 | ↑7.112 | ↑3.133 | ↑2.270 |
| 222 | IPI00887678.1 | LOC654188 similar to peptidylprolyl isomerase A-like | ↑4.920 | ↑7.656 | ↑12.134 | ↑1.770 | ↑6.855 | |
| 223 | IPI00178926.2 | immunoglobulin J chain | ↑2.512 | ↑7.727 | ↑1.629 | ↑40.551 | ↑8.551 | ↑4.742 |
| 224 | IPI00871843.1 | TGM2 | ↑7.112 | ↑7.870 | ↑3.631 | ↑3.736 | ↑3.470 | ↑2.168 |
| 225 | IPI00289862.3 | Secernin-1 | ↑1.959 | ↑7.870 | ↑1.660 | ↑2.148 | ↑4.742 | |
| 226 | IPI00018219.1 | TGFBI Transforming growth factor-beta-induced protein ig-h3 precursor | ↑1.542 | ↑8.241 | ↑17.701 | ↑29.923 | ||
| 227 | IPI00027230.3 | HSP90B1 Endoplasmin precursor | ↑4.742 | ↑8.395 | ↑1.995 | ↑2.512 | ↑4.207 | |
| 228 | IPI00027463.1 | Protein S100-A6 | ↑3.076 | ↑8.395 | ↑2.911 | ↑2.729 | ↑2.884 | |
| 229 | IPI00450768.7 | type I cytoskeletal 17 | ↑2.228 | ↑8.710 | ↑2.333 | ↑3.908 | ↑3.733 | |
| 230 | IPI00449920.1 | IGHV3OR16-13 cDNA FLJ90170 fis | ↑2.089 | ↑9.120 | ↑2.014 | ↑4.365 | ↑4.529 | |
| 231 | IPI00293276.10 | LOC284889; MIF Macrophage migration inhibitory factor | ↑28.314 | ↑9.376 | ↑4.831 | ↑2.355 | ↑1.941 | |
| ... | ... | ... | ... | ... | ... | ... | ... | ... |
| 235 | IPI00028030.3 | COMP Cartilage oligomeric matrix protein precursor | ↑1.660 | ↑12.023 | ↑3.192 | ↑8.930 | ↑55.463 | ↑3.767 |
| 236 | IPI00002745.1 | Cathepsin Z precursor | ↑8.551 | ↑12.706 | ↑6.546 | ↑4.241 | ↑1.941 | |
| 237 | IPI00853163.1 | TYMP 46 kDa protein | ↑5.200 | ↑13.677 | ↑2.630 | |||
| 238 | IPI00329573.9 | COL12A1 Isoform 1 of Collagen alpha-1(XII) chain precursor | ↑4.267 | ↑14.997 | ↑4.366 | ↑19.055 | ↑5.620 | ↑13.804 |
| 239 | IPI00022892.2 | Thy-1 membrane glycoprotein precursor | ↑16.749 | ↑9.290 | ↑1.614 | ↑1.803 | ||
| 240 | IPI00009867.3 | type II cytoskeletal 5 | ↑7.047 | ↑17.865 | ↑2.535 | |||
| 241 | IPI00642455.2 | Thrombospondin 2 | ↑25.586 | ↑1.500 | ↑62.517 | ↑3.664 | ↑17.061 | |
| 242 | IPI00399007.5 | IGHG2 Putative uncharacterized protein DKFZp686I04196 (Fragment) | ↑33.113 | ↑17.701 | ↑34.995 | ↑18.707 | ||
| 243 | IPI00410241.2 | POSTN Periostin, osteoblast specific factor | ↑11.376 | ↑37.325 | ↑3.281 | ↑8.096 |
No, protein number; Accession#, protein IPI number in the database; NGM, normal gastric mucosa; AH, atypical hyperplasia; GPDAC, poorly differentiated gastric adenocarcinoma; LMGAC, lymph node metastasis adenocarcinoma; AH vs. NGM, GPDAC vs. NGM, LMGAC vs. NGM, GPDAC vs. AH, LMGAC vs. AH, and LMGAC vs. GPDAC represent the ratios of protein expression between the two indicated tissues.