Figure 1.

Molecular structure of FGL2. The FGL2 gene contains two exons, which were separated by an intron. The mFGL2 contains the membrane, transmembrane, and extramembrane regions, while sFGL2 only has the extracellular domain. The amino terminal in the FGL2 gene structure is located inside of the membrane, and the carboxyl terminal is located outside of the membrane. mFGL2 is mainly secreted by macrophages, endothelial cells, and T cells, while sFGL2 is secreted by CD4⁺ T cells, CD8⁺ T cells, and Tregs.