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. 2021 Mar 8;17(4):1079–1087. doi: 10.7150/ijbs.56748

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FGL1-involved signaling pathways. A) FGL1 is normally released by the liver in low levels but by cancer in high levels. FGL1 is identified as a major ligand for the inhibitory receptor LAG-3, and its blockade can potentiate anti-tumor T cell responses. B) FGL1 inhibits liver cancer cell proliferation by suppressing Akt signaling. C) The expression of FGL1 is down-regulated through Oxysophocarpine, which suppresses IL-6-mediated JAK2/STAT3 signal activation and subsequently strengthen the effects of anti-LAG-3 immunotherapy. D) FGL1 promotes NSCLC by regulating the PARP1/ Caspase 3 pathway.