Figure 1.

MiR-223KO mice are more susceptible to CCl₄-induced liver fibrosis. WT and miR-223KO mice were treated with CCl₄ twice a week for 4 weeks or 8 weeks. (A) Representative images of Sirius red and α-SMA staining are shown. (B) Fibrotic area per field was quantified. (C) RT-qPCR analyses of the expression profiles of the genes related to fibrogenesis and inflammation in the liver from WT and miR-223KO mice. Values represent means ± SEM (n=5-8/group). ^*P< 0.05, ^**P< 0.01, ^***P< 0.001.