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. Author manuscript; available in PMC: 2021 Apr 27.
Published in final edited form as: Sci Signal. 2020 Oct 27;13(655):eaay9217. doi: 10.1126/scisignal.aay9217

Fig. 8: Proposed mechanism of action of TEPP-46 on TH17 cells.

Fig. 8:

TEPP-46 is an inhibitor of TGF-β1, a function that may be mediated by PKM1 or PKM2. Inhibition of TGF-β1 blocks the differentiation of IL-17 producing TH17 cells while maintaining GM-CSF production.