Table 1 -.
Lability Parameters during Active and Inactive Periods
| TG Controls (n = 6) | ETB-def (n = 7) | |||||
|---|---|---|---|---|---|---|
| Normal Salt | High Salt | Normal Salt | High Salt | 3-way RM ANOVA (p) | ||
| SBP Range (mmHg) | S = 0.0006 | S*G = 0.6177 | ||||
| Active | 72.2 ± 3.1 | 84.2 ± 6.1 | 94.6 ± 5.0G | 113.0 ± 6.1GS | G = 0.0011 | S*TOD = 0.8037 |
| Inactive | 70.2 ± 3.8 | 84.3 ± 4.1 | 90.9 ± 5.0G | 105.0 ± 4.0G | TOD = 0.1404 | G*TOD = 0.2711 |
| S*G*TOD = 0.4544 | ||||||
| SBP SD (mmHg) | S < 0.0001 | S*G = 0.0444 | ||||
| Active | 10.6 ± 0.4 | 12.0 ± 0.2S | 12.7 ± 0.5G | 15.2 ± 0.4GS | G < 0.0001 | S*TOD = 0.0144 |
| Inactive | 9.6 ± 0.2 | 10.0 ± 0.2T | 11.8 ± 0.2G | 13.2 ± 0.4GST | TOD < 0.0001 | G*TOD = 0.9564 |
| S*G*TOD = 0.8546 | ||||||
| HR Range (bpm) | S = 0.0004 | S*G = 0.9134 | ||||
| Active | 255.8 ± 7.5 | 278.0 ± 7.6 | 265.3 ± 8.2 | 285.1 ± 6.2 | G = 0.0365 | S*TOD = 0.3688 |
| Inactive | 242.3 ± 4.3 | 273.7 ± 13.4 | 262.0 ± 8.1 | 293.3 ± 6.0 | TOD = 0.5893 | G*TOD = 0.3518 |
| S*G*TOD = 0.9199 | ||||||
| HR SD (bpm) | S = 0.0025 | S*G = 0.9481 | ||||
| Active | 48.7 ± 1.5 | 41.7 ± 1.2 | 57.9 ± 2.7 | 48.6 ± 1.5S | G = 0.0116 | S*TOD = 0.0378 |
| Inactive | 42.0 ± 3.5 | 36.0 ± 1.6 | 48.3 ± 3.6T | 44.2 ± 2.0 | TOD = 0.0005 | G*TOD = 0.7771 |
| S*G*TOD = 0.1363 | ||||||
SBP: systolic blood pressure, HR: heart rate, Normal salt (0.49% NaCl), High salt (4.0% NaCl), TOD: time of day, G: genotype, S: salt diet. 3-way Repeated Measures ANOVA with Sidak’s post-hoc test for multiple comparisons:
G,
p < 0.05 genotype within salt diet and time of day;
S,
p < 0.05 salt within genotype and time of day;
T,
p < 0.05 time of day within salt and genotype. Mean ± SEM.
Group effect significance indicated by italics.